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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
27/01/2020 |
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Actualizado : |
27/01/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
ESCRIBANO, C.; SARAVIA, A.; COSTA, M.; CASTELLS, D.; CIAPPESONI, G.; RIET-CORREA, F.; FREIRE, T. |
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Afiliación : |
CECILIA ESCRIBANO, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MONIQUE COSTA, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; DANIEL CASTELLS, Secretariado Uruguayo de Lana, Florida, Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; TERESA FREIRE, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay. |
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Título : |
Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Scientific Reports, 1 December 2019, Volume 9, Issue 1, Article number 19579. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-019-55447-6 |
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ISSN : |
2045-2322 |
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DOI : |
10.1038/s41598-019-55447-6 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 21 June 2019 / Accepted: 27 November 2019 / Published: 20 December 2019.
Funding information:
We acknowledge the personnel from Uruguayan Wool Secretariat that assisted with animal studies. This project was funded by INIA (Uruguay) and CSIC-VUSP (Uruguay). C.E. was funded by a scholarship by INIA. |
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Contenido : |
ABSTRACT.
Gastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks.
© 2019, The Author(s). |
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Palabras claves : |
HAEMONCHUS; SHEEP. |
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Asunto categoría : |
L01 Ganadería |
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URL : |
https://www.nature.com/articles/s41598-019-55447-6.pdf
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Marc : |
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001 1060699
005 2020-01-27
008 2019 bl uuuu u00u1 u #d
022 $a2045-2322
024 7 $a10.1038/s41598-019-55447-6$2DOI
100 1 $aESCRIBANO, C.
245 $aResistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response.$h[electronic resource]
260 $c2019
500 $aArticle history: Received: 21 June 2019 / Accepted: 27 November 2019 / Published: 20 December 2019. Funding information: We acknowledge the personnel from Uruguayan Wool Secretariat that assisted with animal studies. This project was funded by INIA (Uruguay) and CSIC-VUSP (Uruguay). C.E. was funded by a scholarship by INIA.
520 $aABSTRACT. Gastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks. © 2019, The Author(s).
653 $aHAEMONCHUS
653 $aSHEEP
700 1 $aSARAVIA, A.
700 1 $aCOSTA, M.
700 1 $aCASTELLS, D.
700 1 $aCIAPPESONI, G.
700 1 $aRIET-CORREA, F.
700 1 $aFREIRE, T.
773 $tScientific Reports, 1 December 2019, Volume 9, Issue 1, Article number 19579. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-019-55447-6
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INIA Las Brujas (LB) |
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| Registros recuperados : 78 | |
| 1. |  | RABAZA, A.; FRAGA, M.; REPETTO, J.; CAJARVILLE, C.; PLA, M.; BANCHERO, G. Acidosis ruminal subaguda en novillos de engorde: uso de haptoglobina para evaluar respuesta inflamatoria causada por el ayuno y realimentación. In: Jornadas Uruguayas de Buiatría, 44., 2016, Paysandú, UY.; Gianneechini, E.; Elizondo, V. (Ed.).Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2016. p.163-165| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| 2. | | BRAMBILLASCA, S.; BRITOS, A.; DELUCA, C.; FRAGA, M.; CAJARVILLE, C. Addition of citrus pulp and apple pomace in diets for dogs: influence on fermentation kinetics, digestion, faecal characteristics and bacterial populations. Archives of Animal Nutrition, v. 67, n. 6, p. 492-502, 2013. Article history: Received 26 July 2013/ Accepted 4 October 2013.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : B - 1 |
| Biblioteca(s): INIA La Estanzuela. |
|  |
| 3. | | ARROYO, J.M.; PÉREZ-RUCHEL, A.; REPETTO, J.; CAJARVILLE, C. Aspectos claves a considerar para lograr aumentos de 300 gramos diarios en engorde intensivos de corderos. In: Jornadas Uruguayas de Buiatría, 46., 2018, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2018. p. 42-51| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Tacuarembó. |
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| 4. | | DINI, Y.; CAJARVILLE, C.; GERE, J.I.; FERNANDEZ. S.; FRAGA, M.; PRAVIA, M.I.; NAVAJAS, E.; CIGANDA, V. Association between residual feed intake and enteric methane emissions in Hereford steers. Translational Animal Science, v. 3, Issue 1, 1 January 2019, Pages 65-72. Doi: https://doi.10.1093/tas/txy111. Article history: Published: 01 October 2018 // Received: 12 September 2018.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 5. | | CAJARVILLE, C.; MENDOZA, A.; SANTANA, A.; REPETTO, J. Avances en el manejo de la alimentación de la vaca lechera para optimizar la producción y calidad de la leche. In: Jornadas Uruguayas de Buiatría, 46., 2018, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2018. p. 51-60.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| 9. | | PASTORINI, M; POMIÉS, N; CAJARVILLE, C.; MENDOZA, A.; CALVO, M.; CONSTANTIN, M; HIRIGOYEN, D.; REPETTO, JOSÉ LUIS.2015 Combinación de ración totalmente mezcla y pastura fresca: efecto sobre el perfil de ácidos grasos de la leche en vacas lecheras. In: JORNADAS URUGUAYAS DE BUIATRÍA, 43., 2015, PAYSANDÚ, UY.; GIANNEECHINI, E.; MATTO, C. (Ed.). [Trabajos presentados]. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría. p.283-285| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| 10. | | PASTORINI, M.; POMIÉS, N.; CAJARVILLE, C.; MENDOZA, A.; ALOY, E.; BAZZANO, M.; CALVO, M.; GAYO, V.; REPETTO, J. Combinación de ración totalmente mezcla y pastura fresca: efecto sobre la producción y composición de la leche en vacas lecheras, In: JORNADAS URUGUAYAS DE BUIATRÍA, 43., 2015, PAYSANDÚ, UY.; GIANNEECHINI, E.; MATTO, C. (Ed.). [Trabajos presentados]. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría. p.250-252.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| 13. | | MENDOZA, A.; CAJARVILLE, C.; FÉLIX, A.; PÉREZ-RUCHEL, A..; DUVOS, M.; IRIARTE, A.; MACHIAVELLO, N.; REPETTO, J. Concentración plasmática de insulina, glucosa y urea en vacas lecheras alimentadas con forraje fresco y ración totalmente mezclada. Veterinaria (Montevideo), v.48, p.150, 2012.| Tipo: Artículos en Revistas Indexadas Nacionales | Circulación / Nivel : B - 5 |
| Biblioteca(s): INIA La Estanzuela. |
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| 14. | | URIOSTE, M.J.; FARIÑA, V.; MARTÍNEZ, V.; CRIADO, L.; PEREIRA, D.; LUZARDO, S.; PÉREZ-RUCHEL, A.; REPETTO, J.; CAJARVILLE, C.; ARROYO, J.M. Correlación entre parámetros de la canal de corderos medidos in vivo por ultrasonografía y post-mortem. [Resumen]. In: CONGRESO ASOCIACIÓN URUGUAYA DE PRODUCCIÓN ANIMAL (6º, Marzo, 2018, Tacuarembó, Uruguay). Resúmenes. Tacuarembó: AUPA, 2018. p. 23| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Tacuarembó. |
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| 15. | | CAPELESSO, A.S.; KOZLOSKI, G.V.; REPETTO, J.; MENDOZA, A.; PLA, M.; AFONSO, E.; PIETRO, E.; SILVA, G.; CAJARVILLE, C. Decreasing milking frequency in early lactation reduces milk yield and alters milk composition in primiparous dairy cows. [Abstract.] Congreso de la Asociación Latinoamericana de Producción Animal, 24.; Congreso de la Sociedad Chilena de Producción Animal, 40., Puerto Varas, Chile, 9 al 13 noviembre 2015. ln: Reunión ALPA (24., Puerto Varas, Chile). Resúmenes. Puerto Varas (Chile): ALPA, 2015. p. 672| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 16. | | URIOSTE, M.J.; LUZARDO, S.; DE SOUZA, G.; PÉREZ RUCHEL, A.; FARIÑA, V.; FERNÁNDEZ, G.; REPETTO, J.L.; CAJARVILLE, C.; ARROYO, J.M. Desempeño de corderos de engorde intensivo alimentados a base de dietas mixtas con distintas fuentes de energía. In: Jornadas Uruguayas de Buiatría, 45., 2017, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos preentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2017. p. 215-217| Biblioteca(s): INIA Tacuarembó. |
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| 18. | | MENDOZA, A.; CAJARVILLE ,C.; REPETTO, J. Digestive response of dairy cows fed diets combining fresh forage with a total mixed ration. Journal of Dairy Science , v. 99, n.11, p. 8779-8789, 2016. Article history: Published online: August 18, 2016.//Accepted: May 11, 2016.//Received: February 11, 2016.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : A - 1 |
| Biblioteca(s): INIA La Estanzuela. |
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| 19. | | CAJARVILLE, C.; BRITOS, A.; ERRANDONEA, N.; GUTIÉRREZ, L.; COZZOLINO, D.; REPETTO, J.L. Diurnal changes in water-soluble carbohydrate concentration in lucerne and tall fescue in autumn and the effects on in vitro fermentation. Research Article. New Zealand Journal of Agricultural Research, 2015, v. 58, no.3, p. 281-291. Article history: Received 23 January 2014 // Accepted 5 February 2015.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 78 | |
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